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Algorithm for arriving at the diagnosis of treatment resistant depression is given BaCkgRounD: Treatment-resistant depression (TRD) presents a unique guidelines recommend dose titration, augmentation, or switching. in the case. 28 Jul 2009 As noted, some treatment guidelines allow 2 SSRI trials before switching classes. For example, in a study by Thase and colleagues,10 58If you've been treated for depression but your symptoms haven't improved, you may have treatment-resistant depression. Taking an antidepressant or going to 9 Feb 2018 To review the current definitions of treatment-resistant depression (TRD) . foster better evidence to translate into clearer guidelines for treating 25 Aug 2016 *American Psychiatric Association (APA), Practice Guideline for the Treatment of Treatment Resistant Depression: Major Depressive Episode. 1 May 2012 May have a role for adjunctive treatment of apathy. Abbreviations: RCTs, randomized controlled trials; FDA, Food and Drug Administration; SSRI, selective serotonin reuptake inhibitor; STAR*D, Sequenced Treatment Alternatives to Relieve Depression; TRD, treatment-resistant depression. 22 Aug 2017 Prior to using ECT, many patients receive a few (eg, one to four) courses of next step pharmacotherapy using the same regimens that are employed for treatment resistant patients with mild to moderate depression; these options include antidepressant monotherapy (see 'Pharmacotherapy' below) as well as combination Depression in adults: treatment and management: NICE guideline short version DRAFT. (July 2017) . 1.9 Limited response and treatment-resistant depression .