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Indications for manual red cell exchange transfusions. THIS IS AN EMERGENCY Patients requiring a central line. Follow local line insertion protocol. Method. Appendix A: Sample Protocol for Pediatric Manual Exchange Transfusion Manual exchange transfusion – Remove patient whole blood (containing sickle. Clinical guideline for health professionals on manual exchange blood transfusion protocol, from Great Ormond Street Hospital. 11 Apr 2017 2Centre National de Transfusion Sanguine, BP 5002, Dakar, Senegal and safety of an easy protocol of manual partial RCE in adult sickle 26 Jun 2015 Optimal Manual Exchange Transfusion Protocol for Sickle Cell Disease: A Retrospective Comparison of Two Comprehensive Care Centers in J Vis Exp. 2017 Mar 14;(121). doi: 10.3791/55172. Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Transfusion may be aimed at either to correct an aggravation of anaemia or to provide non-deformable red cells to deliver oxygen to ischemic tissues in cases of.13 Mar 2017 10 Feb 2012 GSTT/KCH/Lewisham protocol March 2009. Guidelines for manual exchange blood transfusion (EBT) in the emergency setting in adult sickle RBCs may be given by simple transfusion, manual exchange transfusion (ME), During the study period, 38 subjects (42% male) met all inclusion criteria.