Doxycycline is an antibiotic that is used in the treatment of The World Health Organization Guidelines states that the combination of doxycycline with either artesunate or quinine may be used for the meaning the drug is easily absorbed after oral administration and has a large volume of Intrathecal administration of cytarabine is indicated in the prophylaxis and treatment of meningeal leukemia. Several guidelines on this subject have been published. 1-7 There is no general agreement that all of the procedures recommended in the guidelines are necessary or appropriate. Instructions for intrathecal administration . Vanderbilt Ingram Cancer Center Oncology Pharmacy Standard Operating Procedure (SOP) for Preparation and Storage of Intrathecal Chemotherapy R:LIBRARYchemorx working filesSOPs f. Due date of administration administration.) high dose regimens for other neoplastic diseases are investigational and a therapeutic advantage has not been established. methotrexate formulations and diluents containing preservatives must not be used for intrathecal or high dose methotrexate therapy. 1. Routes of Drug Administration. Route Advantages and Disadvantages Examples. STUDY. PLAY. Antibiotics of dental infections, analgesics for dental pain, doxycycline 20 mg for chronic periodontitis. Examples of intrathecal drug administration. Spinal anesthesia. The intrathecal route of administration is effective but has the potential for an increased frequency of adverse effects. Pruritus is the most frequent adverse effect of intrathecal morphine. Concern has also been raised about the possible association of pruritus with re-activation of herpes labialis virus type II. Medicines not FDA approved for intrathecal administration or intrathecal implanted pump use (for example, hydromorphone, bupivacaine, fentanyl, clonidine) ANY mixture of two or more different Guidelines for monitoring serum methotrexate levels, and for adjustment of leucovorin dosing to reduce the r