26 Apr 2019 or a cell-type specific loss of PHD2 strongly increases HIF expression [17]. .. controls the expression of VEGFR2, induces endothelial cell 5LA9: HIF prolyl hydroxylase 2 (PHD2-R281C/V314C) cross-linked to HIF-1alpha NODD-L397C/D412C and N-oxalylglycine (NOG) (complex-2) 7 Jan 2016 Furthermore, we demonstrated that disulfide bond-mediated PHD2 dimerization is associated with the stabilization and activation of HIF-1? PHD2 is therefore the main HIF prolyl hydroxylase isoform which, next to HIF-2? and the von Hippel-Lindau protein (VHL), controls the expression of EPO in However, silencing of PHD2 upregulated HIF-1? similarly to hypoxia or Co2+. We therefore suggest that PHD2 controls steady-state levels of HIF-1? in all cell mouse lungs express decreased mRNA levels of HIF targets and increased levels of PHD2. miR-17~92 inhibitors suppress hypoxia-induced levels of HIF1a,The IUPHAR/BPS Guide to Pharmacology. egl-9 family hypoxia inducible factor 1 - Prolyl hydroxylases. Abbreviated Name: PHD2 EGL nine (C.elegans) homolog 1 | HIF prolyl hydroxylase 2 | HIFPH2 | SM-20 | ZMYND6 | egl-9 family Finally, PHD2 is positively regulated by the HIF pathway itself, as its promoter contains a HRE region.