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May Be Taken With Food Or Milk Or On An Empty Stomach. *The usual dose of oral doxycycline is 200 mg on the first day of treatment (administered 100 mg every 12 hours), followed by a maintenance dose of 100 mg daily. Marginal loss of absorption mitigated by slight dose increase Doryx® MPC 120 mg for 200 mg of doxycycline/day for severe infections. HCPs: For Doryx® Pictures of Doryx (Doxycycline Hyclate), drug imprint information, side effects for the patient. DORYX® (doxycycline hyclate) Delayed-Release Capsules, 75 mg and 100 mg Following a 200 mg dose, normal adult volunteers averaged peak serum of doxycycline hyclate and other antibacterial drugs, DORYX Tablets should be Adults: the usual dose of oral doxycycline is 200 mg on the first day of. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, 200 mg IV on day 1, then 100 to 200 mg IV per day, with the 200 mg dose administered as 1 or 2 Oral dosage (excluding Doryx MPC delayed-release tablets). Tabs may be broken up (in pellets) and sprinkled on a spoonful of applesauce; swallow mixture immediately without chewing and followed by a glass of water. 200mg for 1 day (100mg every 12hrs), then 100mg daily (as a single dose or 50mg every 12hrs); if severe infections (eg, chronic UTI): 100mg every 12 hours. The usual dose of oral doxycycline is 200 mg on the first administer 200 mg by mouth once-a-day for 7 days. How to use Doryx. This medication is best taken by mouth on an empty stomach, at least 1 hour before or 2 hours after a meal, usually 1 or 2 times daily or as directed by your doctor. Take this medication with a full glass of water (8 ounces/240 milliliters) unless directed otherwise.