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8 Sep 2011 The Big C (2010–2013). Episode List. Season: 1, 2, 3, 4. OR Season 4. Quality of Life. S4, Ep1. 29 Apr. 2013. Quality of Life. 8.8 (152). 0. Rate. 1. Rate. 2. Rate. At the end of the second-season finale episode, Paul appears to Cathy as a hallucination at the end of the marathon she runs and then season, Title, Directed by, Written by, Original air date, U.S. 15, 2, "Musical Chairs", Michael Engler, Jenny Bicks, July 4, 2011 In the second season, Cathy (Laura Linney) enters a clinical trial run by a renowned oncologist (Alan Alda) where she meets new friend and cancer Tv Season Info . Click the link below to see what others say about The Big C: Season 2! TVGuide has every full episode so you can stay-up-to-date and watch your favorite show The Big C anytime, anywhere. This season's finale of The Big C didn't move me nearly as much as season one's finale did (I think last week's episode A. Season 2 20 May 2013 After four seasons, Showtime's cancer dramedy The Big C ended its PHOTOS: TV Swan Songs: 9 Shows Ending During the 2012-13 Season.The Big C (TV Series 2010–2013) cast and crew credits, including actors, actresses, directors, writers and more. Gabriel Basso in The Big C (2010) Gabriel Basso and Gabourey Sidibe in The Big C (2010) Episode complete credited cast: TV-MA | See all certifications »